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//! BCF reader.
mod builder;
mod header;
pub(crate) mod query;
pub(crate) mod record;
pub(crate) mod record_buf;
mod record_bufs;
pub use self::{builder::Builder, query::Query, record_bufs::RecordBufs};
use std::{
io::{self, BufRead, Read},
iter, str,
};
use byteorder::ReadBytesExt;
use noodles_bgzf as bgzf;
use noodles_core::Region;
use noodles_csi::BinningIndex;
use noodles_vcf::{self as vcf, header::string_maps::ContigStringMap, variant::RecordBuf};
use self::{header::read_header, record::read_record, record_buf::read_record_buf};
use crate::Record;
/// A BCF reader.
///
/// The BCF format is comprised of two parts: 1) a VCF header and 2) a list of records.
pub struct Reader<R> {
inner: R,
buf: Vec<u8>,
}
impl<R> Reader<R>
where
R: Read,
{
/// Returns a reference to the underlying reader.
///
/// # Examples
///
/// ```
/// use noodles_bcf as bcf;
/// let data = [];
/// let reader = bcf::io::Reader::from(&data[..]);
/// assert!(reader.get_ref().is_empty());
/// ```
pub fn get_ref(&self) -> &R {
&self.inner
}
/// Returns a mutable reference to the underlying reader.
///
/// # Examples
///
/// ```
/// use noodles_bcf as bcf;
/// let data = [];
/// let mut reader = bcf::io::Reader::from(&data[..]);
/// assert!(reader.get_mut().is_empty());
/// ```
pub fn get_mut(&mut self) -> &mut R {
&mut self.inner
}
/// Returns the underlying reader.
///
/// # Examples
///
/// ```
/// use noodles_bcf as bcf;
/// let data = [];
/// let reader = bcf::io::Reader::from(&data[..]);
/// assert!(reader.into_inner().is_empty());
/// ```
pub fn into_inner(self) -> R {
self.inner
}
/// Reads the VCF header.
///
/// This verifies the BCF magic number, discards the file format version, and reads and parses
/// the raw VCF header. Associated string maps are also built from the raw header.
///
/// The position of the stream is expected to be at the start.
///
/// # Examples
///
/// ```no_run
/// # use std::{fs::File, io};
/// use noodles_bcf as bcf;
/// let mut reader = File::open("sample.bcf").map(bcf::io::Reader::new)?;
/// let header = reader.read_header()?;
/// # Ok::<(), io::Error>(())
/// ```
pub fn read_header(&mut self) -> io::Result<vcf::Header> {
read_magic(&mut self.inner)?;
read_format_version(&mut self.inner)?;
read_header(&mut self.inner)
}
/// Reads a single record.
///
/// The stream is expected to be directly after the header or at the start of another record.
///
/// It is more ergonomic to read records using an iterator (see [`Self::records`]), but using
/// this method directly allows the reuse of a single [`vcf::Record`] buffer.
///
/// If successful, the record size is returned. If a record size of 0 is returned, the stream
/// reached EOF.
///
/// # Examples
///
/// ```no_run
/// # use std::{fs::File, io};
/// use noodles_bcf as bcf;
/// use noodles_vcf as vcf;
///
/// let mut reader = File::open("sample.bcf").map(bcf::io::Reader::new)?;
/// let header = reader.read_header()?;
///
/// let mut record = vcf::variant::RecordBuf::default();
/// reader.read_record_buf(&header, &mut record)?;
/// # Ok::<(), io::Error>(())
/// ```
pub fn read_record_buf(
&mut self,
header: &vcf::Header,
record: &mut RecordBuf,
) -> io::Result<usize> {
read_record_buf(&mut self.inner, header, &mut self.buf, record)
}
/// Reads a single record without eagerly decoding (most of) its fields.
///
/// The stream is expected to be directly after the header or at the start of another record.
///
/// It is more ergnomic to read records using an iterator (see [`Self::records`]), but using
/// this method directly allows the reuse of a single [`Record`] buffer.
///
/// If successful, the record size is returned. If a record size of 0 is returned, the stream
/// reached EOF.
///
/// # Examples
///
/// ```no_run
/// # use std::{fs::File, io};
/// use noodles_bcf as bcf;
///
/// let mut reader = File::open("sample.bcf").map(bcf::io::Reader::new)?;
/// reader.read_header()?;
///
/// let mut record = bcf::Record::default();
/// reader.read_record(&mut record)?;
/// # Ok::<(), io::Error>(())
/// ```
pub fn read_record(&mut self, record: &mut Record) -> io::Result<usize> {
read_record(&mut self.inner, record)
}
/// Returns an iterator over records starting from the current stream position.
///
/// The stream is expected to be directly after the reference sequences or at the start of
/// another record.
///
/// # Examples
///
/// ```no_run
/// # use std::{fs::File, io};
/// use noodles_bcf as bcf;
///
/// let mut reader = File::open("sample.bcf").map(bcf::io::Reader::new)?;
/// let header = reader.read_header()?;
///
/// for result in reader.record_bufs(&header) {
/// let record = result?;
/// // ...
/// }
/// # Ok::<(), io::Error>(())
pub fn record_bufs<'r, 'h>(&'r mut self, header: &'h vcf::Header) -> RecordBufs<'r, 'h, R> {
RecordBufs::new(self, header)
}
/// Returns an iterator over lazy records starting from the current stream position.
///
/// The stream is expected to be directly after the header or at the start of another record.
///
/// # Examples
///
/// ```no_run
/// # use std::{fs::File, io};
/// use noodles_bcf as bcf;
///
/// let mut reader = File::open("sample.bcf").map(bcf::io::Reader::new)?;
/// reader.read_header()?;
///
/// for result in reader.records() {
/// let record = result?;
/// println!("{:?}", record);
/// }
/// # Ok::<(), io::Error>(())
/// ```
pub fn records(&mut self) -> impl Iterator<Item = io::Result<Record>> + '_ {
let mut record = Record::default();
iter::from_fn(move || match self.read_record(&mut record) {
Ok(0) => None,
Ok(_) => Some(Ok(record.clone())),
Err(e) => Some(Err(e)),
})
}
}
impl<R> Reader<bgzf::Reader<R>>
where
R: Read,
{
/// Creates a BCF reader.
///
/// # Examples
///
/// ```
/// use noodles_bcf as bcf;
/// let data = [];
/// let reader = bcf::io::Reader::new(&data[..]);
/// ```
pub fn new(reader: R) -> Self {
Self::from(bgzf::Reader::new(reader))
}
}
impl<R> Reader<R>
where
R: bgzf::io::BufRead + bgzf::io::Seek,
{
/// Returns an iterator over records that intersects the given region.
///
/// # Examples
///
/// ```no_run
/// # use std::fs::File;
/// use noodles_bcf as bcf;
/// use noodles_core::Region;
/// use noodles_csi as csi;
///
/// let mut reader = File::open("sample.bcf").map(bcf::io::Reader::new)?;
/// let header = reader.read_header()?;
///
/// let index = csi::read("sample.bcf.csi")?;
/// let region = "sq0:8-13".parse()?;
/// let query = reader.query(&header, &index, ®ion)?;
///
/// for result in query {
/// let record = result?;
/// // ...
/// }
/// # Ok::<(), Box<dyn std::error::Error>>(())
/// ```
pub fn query<'r, 'h, I>(
&'r mut self,
header: &'h vcf::Header,
index: &I,
region: &Region,
) -> io::Result<Query<'r, 'h, R>>
where
I: BinningIndex,
{
let reference_sequence_id = resolve_region(header.string_maps().contigs(), region)?;
let chunks = index.query(reference_sequence_id, region.interval())?;
Ok(Query::new(
&mut self.inner,
header,
chunks,
reference_sequence_id,
region.interval(),
))
}
}
impl<R> From<R> for Reader<R> {
fn from(inner: R) -> Self {
Self {
inner,
buf: Vec::new(),
}
}
}
impl<R> vcf::variant::io::Read<R> for Reader<R>
where
R: BufRead,
{
fn read_variant_header(&mut self) -> io::Result<vcf::Header> {
self.read_header()
}
fn variant_records<'r, 'h: 'r>(
&'r mut self,
_: &'h vcf::Header,
) -> Box<dyn Iterator<Item = io::Result<Box<dyn vcf::variant::Record>>> + 'r> {
Box::new(
self.records().map(|result| {
result.map(|record| Box::new(record) as Box<dyn vcf::variant::Record>)
}),
)
}
}
fn read_magic<R>(reader: &mut R) -> io::Result<()>
where
R: Read,
{
use crate::MAGIC_NUMBER;
let mut buf = [0; 3];
reader.read_exact(&mut buf)?;
if buf == MAGIC_NUMBER {
Ok(())
} else {
Err(io::Error::new(
io::ErrorKind::InvalidData,
"invalid BCF header",
))
}
}
fn read_format_version<R>(reader: &mut R) -> io::Result<(u8, u8)>
where
R: Read,
{
let major_version = reader.read_u8()?;
let minor_version = reader.read_u8()?;
Ok((major_version, minor_version))
}
pub(crate) fn resolve_region(
contig_string_map: &ContigStringMap,
region: &Region,
) -> io::Result<usize> {
let region_name = str::from_utf8(region.name())
.map_err(|e| io::Error::new(io::ErrorKind::InvalidInput, e))?;
contig_string_map.get_index_of(region_name).ok_or_else(|| {
io::Error::new(
io::ErrorKind::InvalidInput,
format!("region does not exist in contigs: {region:?}"),
)
})
}
#[cfg(test)]
mod tests {
use super::*;
#[test]
fn test_read_magic() {
let data = b"BCF";
let mut reader = &data[..];
assert!(read_magic(&mut reader).is_ok());
let data = [];
let mut reader = &data[..];
assert!(matches!(
read_magic(&mut reader),
Err(ref e) if e.kind() == io::ErrorKind::UnexpectedEof
));
let data = b"BAM";
let mut reader = &data[..];
assert!(matches!(
read_magic(&mut reader),
Err(ref e) if e.kind() == io::ErrorKind::InvalidData
));
}
#[test]
fn test_read_format_version() -> io::Result<()> {
let data = [0x02, 0x01];
let mut reader = &data[..];
assert_eq!(read_format_version(&mut reader)?, (2, 1));
Ok(())
}
}